However, Li et al. have also shown that Cetuximab induces autophagy in A431 human vulvar squamous carcinoma cells, DiFi colorectal adenocarcinoma cancer cells, and HCC827 human non-small cell lung cancer cells by downregulating HIF-1α and Bcl-2 and activating the beclin-1/hVps34 complex [32]. The gene discussed is PIK3C3; the disease is non-small cell lung carcinoma.