Reviewing the past studies about DENND1A-rs2479106 polymorphism and the risk of PCOS, Shi et al (9) and Cui et al (17) found an increased risk for PCOS associated with rs2479106 variant allele, Lerchbaum et al (22) and Eriksen et al (18) identified a decreased risk, and the other studies did not detect an association between rs2479106 variant allele and PCOS risk (20,21,23). This evidence concerns the gene DENND1A and polycystic ovary syndrome.