Most of the identified loci were annotated on genes involved in the metabolism of smoking-released chemicals [e.g., AHRR is a repressor of the nuclear receptor for aryl hydrocarbons that is involved in xenobiotic metabolism (Shenker et al. 2013)] or that might be involved in smoking-related health effects [e.g., methylation of F2RL3 mediates the detrimental impacts of smoking and is related to mortality caused by coronary heart disease (Breitling et al. 2012; Zhang et al. 2014)]. The gene discussed is AHRR; the disease is coronary artery disorder.