Gsk3β activating pathways are involved in the localization of PSD95 to synapses in response to neuronal stimulation.41 The localization of PSD95 at excitatory synapses is directly correlated to synaptic strength42 and has a functional consequence with the glutamatergic impairment in psychosis.34 The impairment of PSD95 but not SYN, which we find in our in vivo preparations, can be directly correlated to this pathway as a consequence of the disruption of Gsk3β pathway, and can be related to deficits in synapses strengthening, rather than formation. This evidence concerns the gene DLG4 and psychotic disorder.