GSK3B and psychotic disorder: Indeed, CREB signaling is an important mediator of activity-dependent plasticity in health and disease.18 GSK3β controls molecular pathways dysregulated in several neuropsychiatric disorders,19 and in particular psychosis.20 Although there is evidence for involvement of DISC1 in synaptic transmission in several brain areas,21, 22 functional in vivo validation in response to long-term changes is still lacking.