In vivo, basal expression of PSD95 is significantly downregulated in the visual cortex of juvenile L100P animals (Figure 2), consistent with the impairment of glutamatergic transmission reported in schizophrenia and other disorders;12, 34 this is confirmed by immunoblotting analysis of PSD95 on the whole brain. The gene discussed is DLG4; the disease is schizophrenia.