AKT1 and hepatocellular carcinoma: In our previous studies, we had found that AFP inhibited activity of PTEN to activate PI3K/AKT signal pathway to stimulate expression of Ras, Src and CXCR4 5, 17, 35, 36, and AFP promoted malignant behaviours of HCC cells also through regulating post‐transcription of PTEN 37.