In our previous studies, we had found that AFP inhibited activity of PTEN to activate PI3K/AKT signal pathway to stimulate expression of Ras, Src and CXCR4 5, 17, 35, 36, and AFP promoted malignant behaviours of HCC cells also through regulating post‐transcription of PTEN 37. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.