Finally, in contrast with shCtrl cells, the migration of m6CCR3 cells in response to mu-VAT-CM from obese or lean mice was similar and was not affected by the inhibition of the CCR3/CCL7 axis (Fig. 5f), highlighting again the key role of this axis in the increased prostate cancer migration observed in conditions of obesity. The gene discussed is CCL7; the disease is obesity due to melanocortin 4 receptor deficiency.