Finally, in contrast with shCtrl cells, the migration of m6CCR3 cells in response to mu-VAT-CM from obese or lean mice was similar and was not affected by the inhibition of the CCR3/CCL7 axis (Fig. 5f), highlighting again the key role of this axis in the increased prostate cancer migration observed in conditions of obesity. This evidence concerns the gene CCL7 and Familial prostate cancer.