Finally, we observed that filamin-1 protein expression, which is implicated in actin reticulation, was similar between CMO and DMO both at 3 and 18 months (Fig 3E), whereas profilin-1, which supports actin polymerisation, significantly increased in 18-month-old DMO (Fig 3F). The gene discussed is PFN1; the disease is chronic recurrent multifocal osteomyelitis.