2005; Xue et al. 2007; Sampson et al. 2008; Sullivan et al. 2010a; Bhatia et al. 2012). Chronic Ang II infusion exacerbates hypertension and renal injury to a greater extent in male SHRs compared with females (Sandberg and Ji 2003; Yanes et al. 2006; Sullivan et al. 2007a, 2007b, 2010a; Sampson et al. 2008; Bhatia et al. 2012), and the RAS has been implicated in sex differences in blood pressure and proteinuria in SHRs (Gandhi et al. 1998; Reckelhoff 2001; Fischer et al. 2002; McGuire et al. 2007). This evidence concerns the gene AGT and hypertensive disorder.