Our results are in agreement with a recent report by McFarland et al. [69], which showed that STAT3 activation and STAT3 target gene expression by tumor necrosis factor α (TNF-α) is affected through NF-κB induced expression of IL-6 in glioblastoma cell lines as well as in an in vivo xenograft model. This evidence concerns the gene TNF and glioblastoma.