The up-regulation of cleaved-caspase-5 and caspase-7 provide further evidence of apoptosis, as do other findings that SEMA3A can sensitize tumor cells to curcumin, an anti-cancer agent that promotes apoptosis and poly ADP ribose polymerase (PARP) cleavage induced by SEMA3A [20]. The gene discussed is CASP5; the disease is neoplasm.