More importantly, upregulation of KRAS and activated downstream proteins, p-AKT and p-ERK (Supplementary Figure 4E), were detected after NUTF2P3-001 overexpression in PANC-1 cells, indicating that the lncRNA-NUTF2P3-001 promoted pancreatic cancer progression in vitro via regulating KRAS and its downstream pathways on the other hand. This evidence concerns the gene NUTF2P3 and familial pancreatic carcinoma.