More importantly, downregulation of KRAS and its downstream proteins, p-AKT and p-ERK (Figure 2F), were detected after NUTF2P3-001-siRNA transfection, indicating that the lncRNA-NUTF2P3-001 acted as promoter in pancreatic cancer in vitro and might play a role via regulating KRAS and its downstream pathways. Here, AKT1 is linked to familial pancreatic carcinoma.