Moreover, gain and loss experiments of lncRNA-NUTF2P3-001 were performed to evaluate its role in the proliferation and invasion of pancreatic cancer cell in both vitro and vivo. Meanwhile, the dual-luciferase reporter assay was applied to verify the competitive binding of lncRNA-NUTF2P3-001 and KRAS mRNA with miR-3923. This evidence concerns the gene NUTF2P3 and familial pancreatic carcinoma.