HSF1 and cancer: As shown in Fig. S5A, expression of IER5 and cancer-associated HSF1 target genes (RBM23 and EIF4A2) showed a significant association in bladder cancer (Fig. S5A, r = 0.64 and p < 0.0001 for RBM23, and r = 0.54 and p < 0.0001 for EIF4A2).