Since there is accumulating evidence demonstrating significant roles of circulating FABP4 in insulin resistance, atherosclerosis and cardiovascular events [10, 14, 15, 17, 21–23], the results of the present study support the notion that reduction of FABP4 concentration is one of the important mechanisms by which omega-3 fatty acids prevent the development of cardiovascular disease. The gene discussed is FABP4; the disease is Insulin resistance.