Kanno et al. reported that JunB regulates several genes, such as matrix metalloproteinase-2 (MMP-2), MMP-9 and chemokine (C-C motif) ligand-2 (CCL2), to promote tumor invasion and angiogenesis in VHL-defective renal cell carcinomas [28]. Here, CCL2 is linked to hereditary clear cell renal cell carcinoma.