JUNB and head and neck squamous cell carcinoma: In the present study, we show that the small interfering RNA (siRNA)-mediated knockdown and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (cas9) system (CRISPR/Cas9 [13, 14])-mediated knockout of JunB in HNSCC cells significantly inhibited both invasion and migration in vitro, as well as lung metastasis in vivo.