Four of the 30 CAD risk loci previously reported in individuals of European ancestry (CDKN2B-AS1, COL4A2, CXCL12 and APOE) were detected as independent additional SNPs not in LD (r2 < 0.5) with the lead SNP, which also reached genome-wide significance. This evidence concerns the gene CXCL12 and coronary artery disorder.