GPC3 and hepatocellular carcinoma: Indeed, the sensitivity and specificity for early HCC diagnosis were not highly accurate for each marker (GPC3: 57.5 and 95 %; HSP70: 57.5 and 85 %; GS: 50 and 90 %) as well as in combination (GPC3 + HSP70: 40 and 100 %; GPC3 + GS: 35 and 100 %; HSP70 + GS: 35 and 100 %; GPC3 + HSP70 + GS: 25 and 100 %) [15].