Most of the studied effects of AdipoQ in relation to many health conditions, including CHD, stroke, diabetes, obesity, myocardial infarction (MI) and other CVDs, are related to the circulating levels and effects of adiponectin – the protein encoded by the AdipoQ gene [33, 44, 49–54]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.