OTUB2 and airway hyperresponsiveness: While intestinal levels of OTU2 or OTU6 did not correlate with airway hyperresponsiveness in Cftrtm1UNC mice (P > 0.46), analyses revealed the abundance of total intestinal Lactobacillus to positively correlate (r = 0.61, P = 0.02) with airway hyperresponsiveness in Cftrtm1UNC mice (Fig. 5B).