TP53 and pancreatic neoplasm: Likewise, knockdown of cavin-1 through transduction of cavin-1-shRNA into wild-type MiaPaCa-2 cells achieved the same results as knockdown of mutant p53, while transfection of cavin-1 into the mutant p53 knockdown-MiaPaCa-2 cells reversed and enhanced the invasiveness of the pancreatic cancer cells relative to vector control (Fig. 3C–G).