In summary, PCR and CGH analysis of TCR rearrangements in ALK+ ALCL showed that two-thirds (TCR-αβ and TCRγ-only) demonstrate a major in-frame TCRα clonal rearrangement, which is not accompanied by a comparable major TCRβ clonal population but by minor TCRβ clonal populations that are predominantly in-frame and may originate within or independently to the TCRα clonal population and are not associated with detectable TCRβ protein by immunohistochemistry. This evidence concerns the gene TRGC1 and anaplastic large cell lymphoma.