The vast majority (16 out of 17 tested) of TCR-αβ ALK+ ALCL demonstrated clear evidence of TCRα VJ on at least one allele by CGH and clonal TCRα transcripts were identified by reverse-transcriptase PCR (RT–PCR) in 10 out of 15 CGH-positive cases (Fig. 1b). Here, ALK is linked to anaplastic large cell lymphoma.