According to current guidelines for the treatment of patients with HCV-1/HIV coinfection published by the American Association for the Study of Liver Diseases (AASLD) [28], simeprevir + PegIFNα-2a + RBV is recommended as an alternative regimen for treatment-naïve or treatment experienced (prior PEG/RBV relapse) HIV/HCV- coinfected patients with genotype 1 who are eligible to receive IFN. Here, IFNA1 is linked to liver disorder.