However, the main safety concern for PQ administration is the risk of acute haemolytic anaemia (AHA) in G6PD-deficient (G6PDd) individuals, who are uniquely vulnerable to oxidative stresses, as their erythrocytes do not have alternative pathways for G6PD-dependent, reduced nicotinamide adenine dinucleotide phosphate (NADPH) production, essential to maintain their two main anti-oxidant defenses, reduced glutathione and catalase [10]. The gene discussed is G6PD; the disease is autoimmune hemolytic anemia.