The authors proposed an influence of the rs1888747 polymorphism in the FRMD3 promoter on transcriptional regulation within the bone morphogenetic protein (BMP)-signaling pathway [41], suggesting that the transcriptional coregulation of BMP pathway members and FRMD3 might be mediated by the four transcription factor binding site (TFBS) promoter modules in the functional context of DKD [42]. This evidence concerns the gene FRMD3 and diabetic kidney disease.