Comparing transcript profiles of the WT-TPA and Ts-TPA groups, the gene set for an intrinsic group in head and neck squamous cell carcinoma (HNSCC) [31] was significantly up-regulated in TPA-treated trisomic keratinocytes (normalized p-value<0.001) (Fig 3F). The gene discussed is PLAT; the disease is head and neck squamous cell carcinoma.