Parasite infection can induce IgE antibodies that cross react with aeroallergens, this has been described for Wuchereria bancrofti for helminth glutathione-S transferase and the aeroallergen Bla g 5 from cockroach [35], and for tropomyosin from filarial and ascaris that can cross react with dust mites and cockroach [36,37]. Here, IGHE is linked to parasitic infectious disease.