LGALS3 and systemic sclerosis: In regard to circulating Galectin-3 levels several studies have already reported that Galectin-3 protein levels in body fluids significantly correlate with the donors state of health in several diseases, such as various types of cancer [57–63] including osteosarcoma [64], systemic sclerosis [65], inflammatory diseases [66], Alzheimer's disease [67], Diabetes mellitus, type 2 [68] or chronic heart failure [69].