In patients with antiphospholipid syndrome, an acquired autoimmune disorder of arterial or venous thrombosis and/or pregnancy morbidity in the presence of antiphopholipid antibodies, their was the presence of proteins NEDD8, RhoA, Hsp60, annexin I-II, and protein disulfide isomerase which are all related to procoagulant states46. This evidence concerns the gene P4HB and antiphospholipid syndrome.