In the adaptive immune system, vitamin D downregulates expression of proteins involved in T helper type 1 (Th1) cell-driven autoimmunity, and participates in inhibition of antigen-presenting activity, antibody production, lymphocyte proliferation, dendritic cell differentiation and release of cytokines such as interleukin-2 (IL-2), IL-6, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) [11–13]. Here, TNF is linked to Autoimmunity.