Interestingly, mice injected with tet-on CaSm Panc-1 cells demonstrated significantly greater weight loss over the course of the study compared with mice injected with the control tet-on driver Panc-1 cells; by the time of killing, mice injected with the tet-on driver Panc-1 cells had lost an average of 0.65 g in body weight, whereas the mice injected with tet-on CaSm Panc-1 cells lost an average of 2.1 g (Figure 6d), implying a previously unseen role for CaSm overexpression in cancer-related cachexia. This evidence concerns the gene LSM1 and Cachexia.