Although there was no difference in primary tumor burden (Supplementary Figure 4), when normalized to total liver tissue area, tet-on CaSm Panc-1 cells produced significantly more metastatic lesions (4.523±0.21 tumors per 100 mm2 vs 1.775±0.20 tumors per 100 mm2 in the driver controls; Figure 6c), revealing that CaSm expression contributes to PC metastasis in vivo. The gene discussed is LSM1; the disease is neoplasm.