MET and carcinoma: During carcinoma progression, EMT is generally accepted as a means by which cancer cells gain invasive capabilities and break free from the confines of the primary tumor.2, 26 Several investigations have suggested that MET may be important for metastatic colonization by reactivating cell signaling pathways and/or facilitating attachment to heterologous cells within the healthy tissue.10, 11, 27 Like these previous studies, the present work also suggests that CS-99 human carcinosarcoma cells require MET to efficiently metastasize in the lungs.