Tat-Beclin-1 did not clearly increase the infarct volume nor worsen the neurobehavioral functions compared to MCAO rats; however, the effects of GM1 on cerebral infarction reduction and neurobehavioral improvement were abolished by Tat-Beclin-1(P<0.05, Fig 4A and 4B). The gene discussed is BECN1; the disease is brain infarction.