GLS2 and hepatocellular carcinoma: Considering that GLS2 is frequently down-regulated in HCC (Hu et al., 2010; Liu et al., 2014a; Suzuki et al., 2010; Xiang et al., 2015), our findings that GLS2 inhibits HCC metastasis and loss of GLS2 promotes HCC metastasis provide a novel mechanism contributing to high metastatic characteristic of HCC.