Around the same time, using immunofluorescence microscopy with Tau-1 antibody (which detects dephosphorylated tau), tau was localised within the nucleus of CG human neuroblastoma cells, specifically at the nucleolar organiser region (NOR) of the acrocentric chromosomes in dividing cells—the site of rRNA genes; and the fibrillar region of the nucleolus in the interphase cells—the site of rRNA transcription [3]. The gene discussed is MAPT; the disease is neuroblastoma.