Therefore, in AD, nuclear tau binding and protecting the DNA [52] or stabilizing the heterochromatin [62]; could be altered due to the change in the tau molecule configuration, such as phosphorylation, leading to its detachment from the DNA [73,77] and nuclear depletion [119], as a result, causing the alteration of chromatin integrity [65,103] and aberrant gene regulation. The gene discussed is MAPT; the disease is Alzheimer disease.