Indeed, recent findings from Drosophila melanogaster model of tauopathy, mouse model and evidence from human AD brain tissue revealed a central role of tau hyperphosphorylation in the induction of oxidative stress; DNA double-strand-breaks (DSBs); decompaction of the heterochromatin; aberrant gene dysregulation, especially of genes previously masked in the heterochromatin; cell cycle re-entry and neuronal apoptosis [65]. Here, MAPT is linked to Alzheimer disease.