MAPT and supranuclear palsy, progressive, 1: Tauopathies including some variants of frontotemporal lobar degeneration, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), tangle predominant senile dementia (TPSD), argyrophilic grain disease (AGD), and chronic traumatic encephalopathy (CTE) are also neurodegenerative conditions characterized by the accumulation of tau protein in the brain.