Further validation studies of 18F-AV1451 autoradiography using postmortem tissues show a strong binding of 18F-AV1451 in AD brain sections containing PHF-tau, but no remarkable binding to non-AD tau deposits including those in Pick’s disease, CBD, PSP, or to amyloid-β, α-synuclein, and TDP-43 lesions [73]. This evidence concerns the gene MAPT and Pick disease.