As early as 1986, Pollock and colleagues reported that the filamentous aggregates in Pick’s disease (now part of the group of disorders classes as frontotemporal lobar degeneration, FTLD, and called frontotemporal dementia, FTD), progressive supranuclear palsy (PSP) and AD shared the antigenic determinants of tau [127]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.