At that time, an additional eight mutations in the MAPT gene had been reported by two other groups: Poorkaj et al. reported two exonic mutations (P301L and V337M) in two families with FTDP-17 [139], while Hutton et al. reported six different mutations in 10 families: three of these mutations (G272V, P301L and R406W) were missense mutations in exons, while the other three were in the 5' splice site of exon 10 [140]. This evidence concerns the gene MAPT and semantic dementia.