Interestingly enough, out of four other known mutations within the Aβ part of APP (exons 16 and 17) two also cause fatal hemorrhage due to amyloid angiopathy (APP C692G-Flemish and APP E693K-Italian), while only rare “Arctic” (APP E693G) and Osaka (APP E693Δ) mutations cause early-onset AD (EOAD). Here, APP is linked to Alzheimer disease.