They also demonstrated the roles of MFAP5 in enhancing cancer cell motility and invasion potential in ovarian cancer and showed that the tumor-promoting roles of CAF-derived MFAP5 are mediated via the activation of the calcium-dependent FAK/CREB/troponin C type 1 (TNNC1) signaling pathway in ovarian cancer cells by engaging the αVβ3 integrin receptors [90]. Here, CREB1 is linked to ovarian carcinoma.