Examples of DAMPs mobilization which have been found associated with OV infection of cancer cells include cell-surface exposure of calreticulin (ecto-CRT) (in Ad infections); extracellular release of high mobility group box 1 (HMGB1) (Ad, HSV, MV, VV, and PV); ATP secretion (Ad, VV, coxsackievirus B3, PV); release of heat shock protein (PV); and release of various inflammatory cytokines (MV) (recently reviewed in [21]). The gene discussed is HMGB1; the disease is cancer.