Treatment with peduncles of Hovenia dulcis decreased the serum levels of ALT and AST, decreased the liver malondialdehyde (MDA) level and restored liver antioxidant enzymes such as SOD, glutathione S-transferase (GST) and glutathione peroxidase (GSH) in alcohol-induced liver injury mice [63]. This evidence concerns the gene SOD1 and alcohol dependence.