In addition, bacterial DNA and LPS can activate mononuclear phagocytic cells through a series of intracellular signal transduction, activating NF-κB and rapidly inducing synthesis of TNF-α, IL-6 mRNA and releasing a large number cytokines and inflammatory mediators such as TNF-α and IL-6, eventually mediating the occurrence of sepsis [25,26,27]. Here, TNF is linked to Sepsis.