TLR9 and Sepsis: On the one hand, TLR9 stimulation protects cardiomyocytes from stress by inhibition of SERCA2 (sarco/endoplasmic reticulum calcium ATPase) [35], attenuates cardiac dysfunction in sepsis [36], mediates cardioprotection by reducing infarct size in a postconditioning manner [14], and plays a protective role in Th1 modulation and in deep vein thrombogenesis [17].