In order to establish that ADAM28, ADAMDEC1 and COBLL1 are regulated by EBNA3C during viral infection of B cells–and to determine whether EBNA3A and/or EBNA3B are involved in the regulation–primary CD19+ cells were infected with previously characterised wild type (B95.8-BAC) EBV or recombinant EBNA3 KO or revertant (Rev) viruses (Fig 1A–1C) [54]. Here, COBLL1 is linked to viral infectious disease.