Finally, in order to determine whether binding of EBNA3C to RBPJ was necessary for the repression of the endogenous COBLL1 and ADAM28-ADAMDEC1 locus, RNA samples taken every 5 days from the time of infection of primary B cells with the recombinant RBPJ BM EBNA3C virus were analysed. This evidence concerns the gene RBPJ and infection.