In order to determine whether binding of EBNA3C to RBPJ is necessary for the repression of the endogenous COBLL1 and ADAM28-ADAMDEC1 locus in the context of infection, a new EBV recombinant encoding the RBPJ binding mutant of EBNA3C (RBPJ BM EBNA3C) was constructed. This evidence concerns the gene RBPJ and infection.