After establishing that all three genes were robustly repressed after infection of primary B cells with EBV, which confirmed previous findings from stable cell lines that ADAM28 and ADAMDEC1 were repressed by EBNA3C and EBNA3A and identifying that COBLL1 was repressed by EBNA3C alone, we wanted to determine whether it was possible to recapitulate this repression in LCLs carrying EBV-recombinants conditional for EBNA3C (3CHT). This evidence concerns the gene ADAM28 and infection.