The observed repression of ADAM28, ADAMDEC1 and COBLL1 in the 3CHT system was a direct consequence of the HT-induced activation of EBNA3C, because adding HT to a non-conditional EBNA3C KO LCL, grown out from the primary B cell infection (see below), did not change the expression levels of any of the three genes (S1C–S1E Fig). The gene discussed is COBLL1; the disease is infection.