Having shown that the EBNA3C conditional system could be efficiently used to replicate gene expression changes seen early after EBV infection of primary B cells, we wanted to determine the sequence of events that led to such robust repression of COBLL1 and the ADAM28-ADAMDEC1 locus by employing chromatin immunoprecipitations (ChIP) on samples harvested throughout the 3CHT A13 time-course. Here, ADAM28 is linked to Epstein-Barr virus infection.