TARDBP and amyotrophic lateral sclerosis: The exposure of D247 in the misfolded TDP-43 was demonstrated by our monoclonal antibody 3B12A, which recognizes mislocalized TDP-43 in cultured cells, the skein-like or round inclusions in ALS patients24, and aggregated forms of TDP-43 with C173/C175 substitutions (Supplementary Fig. S5).