Thus, this study was designed to test whether activation of TGF-β/periostin pathway is associated with myocardial fibrosis of DCM in STZ-induced diabetic mice and to evaluate whether resveratrol ameliorates fibrogenesis by modulating ROS/ERK/TGF-β/periostin pathway in vivo and in vitro. The gene discussed is POSTN; the disease is Myocardial fibrosis.