Since glutathionylation of Cav1.2 occurs in the ischemic human heart25, and increased calcium influx through Cav1.2 is sufficient to induce hypertrophic growth23, 40 direct regulation of Cav1.2 channel protein during reperfusion may contribute to the pathology associated with ischemic heart disease. This evidence concerns the gene CACNA1C and coronary artery disorder.