BLBD-3 and BLBD-6 share a common sequence in the activation region of the β-catenin/LEF-1 binding domain (ATDEMIPF); thus, we mutated the activation region (GTDEAAAA, TAT-NLS-BLBD-6m) and found that TAT-NLS-BLBD-6m did not affect the growth of breast cancer cells compared with TAT-NLS-BLBD-6 (Fig. 1b). The gene discussed is LEF1; the disease is breast cancer.