In our study, the CBS 68 bp insertion allele (I) was neither associated with OSCC risk nor with heterozygous genotype (I/N) or polymorphic homozygous genotype (I/I), corroborating the results of Galbiatti et al.,32 but unlike results for other tumor types such as prostate and upper gastrointestinal tract cancers.33, 34. Here, CBS is linked to neoplasm.