Aberrant OVOL2 expression levels are likely to have a range of downstream consequences; however, given that it is a known direct repressor of ZEB1 (an established PPCD-associated gene), it seems plausible that dysregulation of this OVOL2-ZEB1 regulatory feedback loop is most likely relevant to the mechanism of pathogenesis.33 The gene discussed is OVOL2; the disease is posterior polymorphous corneal dystrophy.