The significant correlations among the cytokines (G-CSF, IL-6, IL-8, MCP-1, MCP-3, MDC and MIP-1β) suggested that the cytokine networks play important roles in inflammation and IOP elevations in APAC, although the exact mechanism of the interactions among these cytokines are unclear. This evidence concerns the gene CCL4 and aldosterone-producing adrenal cortex adenoma.