MAPT and Alzheimer disease: In addition, while no amplitude differences in muscle action potentials of Tau−/− were found, further studies are needed to clarify the impact of loss of Tau on neuromuscular junction by aging as Tau‐related pathology in motor neurons has been shown to have neuromuscular junction malfunction and motor deficits in AD Tg models (Zhang et al., 2005; Ubhi et al., 2007).