Accordingly, in addition to Myo5B knockout (KO) mice (Cartón-García et al., 2015), mice in which the intestinal Rab8a, Rab11a or Cdc42 genes have been individually deleted also develop the cellular hallmarks of MVID (Melendez et al., 2013; Sakamori et al., 2012; Sato et al., 2007; Sobajima et al., 2014). This evidence concerns the gene MYO5B and microvillus inclusion disease.