Mutagenesis of residues in myosin Vb that mediate this protein's interaction with either RAB11A or RAB8A, and the subsequent introduction of these mutant forms into myosin Vb-silenced human Caco-2 cells (Caucasian colon adenocarcinoma), revealed that the uncoupling of myosin Vb from both RAB11A and RAB8A forms the basis of MVID pathogenesis (Knowles et al., 2014). The gene discussed is RAB11A; the disease is microvillus inclusion disease.